CASTLE: The database of CArboxylic eSTer hydroLasE enzymes

Classification of Carboxylic Ester Hydrolases (CEH): families and clans

Clan A Clan B Clan C Clan D Clan E

Carboxylic ester hydrolases (CEHs), the enzymes from EC 3.1.1.1 to 3.1.1.99, catalyze the hydrolysis of ester bonds into alcohols and carboxylic acids. They are one of the enzyme groups that are most explored industrially for their applications in pharmaceuticals, foods, flavors, detergents, and organic syntheses.

The purpose of this database is to provide the scientific community with a useful source of information on these enzymes that can help predict active sites, catalytic residues, and mechanisms of individual sequences, as well as providing a standardized nomenclature.

For more information and definitions, refer to the "What is CASTLE?" section.